Utility Assessment of Moderate to Severe Thyroid Eye Disease Health States.

ABSTRACT:

Importance

Thyroid eye disease (TED) results in varying degrees of proptosis and diplopia negatively affecting quality of life (QoL), producing possibly substantial visual changes, disfigurement, and disability.

Objective

To determine the association of varying TED severities with QoL in a non-TED population by assessing health state utility scores.

Design, setting, and participants

This qualitative study, conducted from April 20, 2020, to April 29, 2021, assessed health states for active, moderate-severe TED, and values were elicited using time trade-off methods. Six health states of varying severity were determined from 2 placebo-controlled clinical trials (171 patients with TED and clinical activity score ≥4, ±diplopia/proptosis) and refined using interviews with U

SUBMITTER: Smith TJ 

PROVIDER: S-EPMC9857514 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature