Risk of Bias in Randomized Clinical Trials Comparing Transcatheter and Surgical Aortic Valve Replacement: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Recent European Society of Cardiology/European Association for Cardio-Thoracic Surgery (ESC/EACTS) guidelines highlighted some concerns about the randomized clinical trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for aortic stenosis. Quantification of these biases has not been previously performed.

Objective

To assess whether randomization protects RCTs comparing TAVI and SAVR from biases other than nonrandom allocation.

Data sources

A systematic review of the literature between January 1, 2007, and June 6, 2022, on MEDLINE, Embase, and Cochrane Central Register of Controlled Trials was performed. Specialist websites were also checked for unpublished data.

Study selection

The study

SUBMITTER: Barili F 

PROVIDER: S-EPMC9857525 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature