Association of Appropriate Empirical Antimicrobial Therapy With In-Hospital Mortality in Patients With Bloodstream Infections in the US.

ABSTRACT:

Importance

Bloodstream infections (BSIs) are a major public health problem associated with high morbidity. Little evidence exists regarding the epidemiology of BSIs and the use of appropriate empirical antimicrobial therapy.

Objective

To estimate the association between receipt of appropriate initial empirical antimicrobial therapy and in-hospital mortality.

Design, setting, and participants

This retrospective cross-sectional study used data from the Premier Healthcare database from 2016 to 2020. The analysis included 32 100 adult patients (aged ≥18 years) with BSIs from 183 US hospitals who received at least 1 new systemic antimicrobial agent within 2 days after blood samples were collected during the hospitalization. Patients with polymicrobial infections were exclu

SUBMITTER: Ohnuma T 

PROVIDER: S-EPMC9857618 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature