Association of Body Mass Index With the Safety Profile of Nivolumab With or Without Ipilimumab.

ABSTRACT:

Importance

Increased survival with immune checkpoint inhibitors has been reported for patients with obesity vs a normal body mass index (BMI). However, the association of obesity with the safety of immune checkpoint inhibitors warrants study.

Objective

To investigate associations between BMI and immune-related adverse events (irAEs) among patients with advanced cancers treated with nivolumab monotherapy and nivolumab plus ipilimumab combination therapy.

Design, setting, and participants

This study was a retrospective pooled analysis of 3772 patients from 14 multicenter CheckMate clinical trials across 8 tumor types. Patients with advanced cancers received nivolumab, 3 mg/kg (n = 2746); nivolumab, 3 mg/kg, plus ipilimumab, 1 mg/kg (n = 713); or nivolumab, 1 mg/kg, plus

SUBMITTER: McQuade JL 

PROVIDER: S-EPMC9857666 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature