Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.

ABSTRACT: The transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty-six transcription factors are dysregulated and co-expressed in most of the lung cancer and pulmonary arterial hypertension datasets, which makes them the most frequently dysregulated transcription factors. Co-expression, gene regulatory, coregulatory, and transcriptional regulatory networks, along with fibration symmetries, were constructed to identify common connection patterns, alignments, main regulators, and target genes in order to analyze transcription factor complex formation, as well as its synchronized co-expression patterns in every type of lung cancer. The regulatory function of the most frequently dysregul

SUBMITTER: Otalora-Otalora BA 

PROVIDER: S-EPMC9857713 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature