Long-term Trajectories of Physical Function Decline in Women With and Without Cancer.

ABSTRACT:

Importance

Patients with cancer experience acute declines in physical function, hypothesized to reflect accelerated aging driven by cancer-related symptoms and effects of cancer therapies. No study has examined long-term trajectories of physical function by cancer site, stage, or treatment compared with cancer-free controls.

Objective

Examine trajectories of physical function a decade before and after cancer diagnosis among older survivors and cancer-free controls.

Design, setting, and participants

This prospective cohort study enrolled patients from 1993 to 1998 and followed up until December 2020. The Women's Health Initiative, a diverse cohort of postmenopausal women, included 9203 incident cancers (5989 breast, 1352 colorectal, 960 endometrial, and 902 lung) match

SUBMITTER: Cespedes Feliciano EM 

PROVIDER: S-EPMC9857739 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature