Prenatal and Infant Exposure to Acid-Suppressive Medications and Risk of Allergic Diseases in Children.

ABSTRACT:

Importance

Existing observational data have indicated positive associations of acid-suppressive medication (ASM) use in prenatal and early life with allergic diseases in children; however, no study to date has accounted for confounding by indication or within-familial factors.

Objective

To evaluate the association of prenatal or infant exposure to ASMs with risk of allergic diseases in children.

Design, setting, and participants

This nationwide, cohort study included data from South Korea's National Health Insurance Service mother-child-linked database from January 1, 2007, to December 31, 2020. Participants included mother-child pairs of neonates born from April 1, 2008, to December 31, 2019.

Exposures

Prenatal and infant exposure to ASMs (histamine 2 receptor

SUBMITTER: Noh Y 

PROVIDER: S-EPMC9857801 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature