Association of Plasma High-Density Lipoprotein Cholesterol Level With Risk of Fractures in Healthy Older Adults.

ABSTRACT:

Importance

Increased levels of high-density lipoprotein cholesterol (HDL-C) have been associated with osteoporosis. Preclinical studies have reported that HDL-C reduces bone mineral density by reducing osteoblast number and function. However, the clinical significance of these findings is unclear.

Objective

To determine whether higher HDL-C levels are predictive of an increased fracture risk in healthy older adults.

Design, setting, and participants

This cohort study is a post hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial and the ASPREE-Fracture substudy. ASPREE was a double-blind, randomized, placebo-controlled primary prevention trial of aspirin that recruited participants between 2010 and 2014. These comprised commu

SUBMITTER: Hussain SM 

PROVIDER: S-EPMC9857824 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature