Lavender Essential Oil Modulates Hepatic Cholesterol Metabolism in HepG2 Cells.

ABSTRACT: Cholesterol is an essential lipid that guarantees several biological processes in eukaryotic cells. Its metabolism is regulated by a complex protein network that could be significantly influenced by numerous exogenous sources, such as essential oils (EOs). For instance, it has been speculated that monoterpenoid and sesquiterpenoid compounds contained in lavender essential oil (LEO) may exert important hypocholesterolemic activities. However, the molecular mechanisms by which LEO influences cholesterol homeostasis are not characterized. In this work, we evaluated the ability of LEO to regulate the protein network that controls cholesterol metabolism in the HepG2 cell line. The main findings indicate that LEO administration increases intracellular cholesterol content. Concurrently, LEO affec

SUBMITTER: Martella N 

PROVIDER: S-EPMC9857966 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature