Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older-RCT.

ABSTRACT:

Objective

Altitude travel is increasingly popular also for middle-aged and older tourists and professionals. Due to the sensitivity of the central nervous system to hypoxia, altitude exposure may impair visuomotor performance although this has not been extensively studied. Therefore, we investigated whether a sojourn at moderately high altitude is associated with visuomotor performance impairments in healthy adults, 40y of age or older, and whether this adverse altitude-effect can be prevented by acetazolamide, a drug used to prevent acute mountain sickness.

Methods

In this randomized placebo-controlled parallel-design trial, 59 healthy lowlanders, aged 40-75y, were assigned to acetazolamide (375 mg/day, n = 34) or placebo (n = 25), administered one day before ascent and whi

SUBMITTER: Reiser AE 

PROVIDER: S-EPMC9858039 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature