VOCs from Exhaled Breath for the Diagnosis of Hepatocellular Carcinoma.

ABSTRACT:

Background

Volatile organic compound (VOC) profiles as biomarkers for hepatocellular carcinoma (HCC) are understudied. We aimed to identify VOCs from the exhaled breath for HCC diagnosis and compare the performance of VOCs to alpha-fetoprotein (AFP). The performance of VOCs for predicting treatment response and the association between VOCs level and survival of HCC patients were also determined.

Methods

VOCs from 124 HCC patients and 219 controls were identified using the XGBoost algorithm. ROC analysis was used to determine VOCs performance in differentiating HCC patients from controls and in discriminating treatment responders from non-responders. The association between VOCs and the survival of HCC patients was analyzed using Cox proportional hazard analysis.

Results</

SUBMITTER: Sukaram T 

PROVIDER: S-EPMC9858163 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature