Effect of silver nanoparticles associated with fluoride on the progression of root dentin caries in vitro.

ABSTRACT:

Objectives

To assess the anti-proteolytic effect and potential to inhibit dentin root caries progression of a silver nanoparticle and fluoride solution (CNanoF) in comparison to silver diamine fluoride (SDF).

Methods

48 specimens of root dentin artificial caries lesion were treated with 38% SDF, CNanoF, CNano or F (n = 6 per group). Ph cycling with demineralization and remineralization solutions simulated caries lesion progression. In addition, specimens were incubated with or without bacterial collagenase in the remineralization solution to induce dentin proteolytic degradation. Dentin degradation was assessed by weight loss rate and hydroxyproline (Hyp) release. Changes in cross-sectional microhardness, and lesion permeability and collagen integrity as determined by confoc

SUBMITTER: Dias FA 

PROVIDER: S-EPMC9858332 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature