Identification and Validation of Three m6A Regulators: FTO, HNRNPC, and HNRNPA2B1 as Potential Biomarkers for Endometriosis.

ABSTRACT:

Background

N6-methyladenosine is involved in numerous biological processes. However, the significance of m6A regulators in endometriosis is still unclear.

Methods

We extracted three significant m6A regulators between non-endometriosis and endometriosis patients from GSE6364 and then we used the random forest model to obtain significant m6A regulators. In addition, we used the nomogram model to evaluate the prevalence of endometriosis. The predictive ability of the candidate genes was evaluated through the receiver operating characteristic curves, while the expression of candidate biomarkers was validated via Western blotting. Additionally, according to candidate genes, we identified m6A subtypes based on which functional enrichment analysis and immune infiltration were perfo

SUBMITTER: Sun J 

PROVIDER: S-EPMC9858668 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature