A conserved motif suggests a common origin for a group of proteins involved in the cell division of Gram-positive bacteria.

ABSTRACT: DivIVA, GpsB, FilP, and Scy are all involved in bacterial cell division. They have been reported to interact with each other, and although they have been the subject of considerable research interest, not much is known about the molecular basis for their biological activity. Although they show great variability in taxonomic occurrence, phenotypic profile, and molecular properties, we find that they nevertheless share a conserved N-terminal sequence motif, which points to a common evolutionary origin. The motif always occurs N-terminally to a coiled-coil helix that mediates dimerization. We define the motif and coiled coil jointly as a new domain, which we name DivIVA-like. In a large-scale survey of this domain in the protein sequence database, we identify a new family of proteins potentia

SUBMITTER: Martinez-Goikoetxea M 

PROVIDER: S-EPMC9858780 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature