Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish.

ABSTRACT: Streptococcus pneumoniae (pneumococcus) is one of the most frequent causes of pneumonia, sepsis and meningitis in humans, and an important cause of mortality among children and the elderly. We have previously reported the suitability of the zebrafish (Danio rerio) larval model for the study of the host-pathogen interactions in pneumococcal infection. In the present study, we characterized the zebrafish innate immune response to pneumococcus in detail through a whole-genome level transcriptome analysis and revealed a well-conserved response to this human pathogen in challenged larvae. In addition, to gain understanding of the genetic factors associated with the increased risk for severe pneumococcal infection in humans, we carried out a medium-scale forward genetic screen in zebrafish. In t

SUBMITTER: Saralahti AK 

PROVIDER: S-EPMC9858863 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature