A meta-epidemiological study on the reported treatment effect of pregabalin in neuropathic pain trials over time.

ABSTRACT:

Background

Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results.

Methods

This meta-epidemiological study aimed to assess change in the reported effectiveness of pregabalin in neuropathic pain trials over time, and if a change is present, determine any associated factors.

Data sources

We performed electronic searches for published trials in Medline, Embase and Cochrane Central Register of Controlled Trials databases; and unpublished trials on ClinicalTrials.gov, the EU Clinical Trials Register, and the Australia New Zealand Clinical Trials Registry

SUBMITTER: Cheng ETL 

PROVIDER: S-EPMC9858874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature