Integrative Analysis of miRNAs Involved in Fat Deposition in Different Pig Breeds.

ABSTRACT:

Background

miRNAs are a set of small, noncoding RNAs that bind to partially complementary sequences on target mRNAs. This leads to the post-transcriptional regulation of gene expression. Many studies have shown that microRNAs play critical roles in adipose cell differentiation and fat metabolism. The aim of this study was to explore the regulatory functions of miRNAs in fat deposition for the prevention and therapy of lipid metabolism-related diseases.

Methods

The significant differences in the fat deposition of Laiwu (LW) pigs and Large White (LY) pigs were studied. To investigate the genetic relationships of miRNAs that regulate fat deposition, we performed a genome-wide analysis of miRNAs derived from subcutaneous adipose tissue of LW and LY pigs using RNA-seq.

Results

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9859024 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature