Are Alzheimer's and coronary artery diseases genetically related to longevity?

ABSTRACT:

Introduction

In the last decade researchers have attempted to investigate the shared genetic architecture of longevity and age-related diseases and assess whether the increased longevity in certain people is due to protective alleles in the risk genes for a particular condition or whether there are specific "longevity" genes increasing the lifespan independently of age-related conditions' risk genes. The aim of this study was to investigate the shared genetic component between longevity and two age-related conditions.

Methods

We performed a cross-trait meta-analysis of publicly available genome-wide data for Alzheimer's disease, coronary artery disease and longevity using a subset-based approach provided by the R package ASSET.

Results

Despite the lack of strong genet

SUBMITTER: Bellou E 

PROVIDER: S-EPMC9859055 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature