Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts.

ABSTRACT:

Background

The risk factors and clinical outcomes of quantitative interstitial abnormality progression over time have not been characterized.

Research questions

What are the associations of quantitative interstitial abnormality progression with lung function, exercise capacity, and mortality? What are the demographic and genetic risk factors for quantitative interstitial abnormality progression?

Study design and methods

Quantitative interstitial abnormality progression between visits 1 and 2 was assessed from 4,635 participants in the Genetic Epidemiology of COPD (COPDGene) cohort and 1,307 participants in the Pittsburgh Lung Screening Study (PLuSS) cohort. We used multivariable linear regression to determine the risk factors for progression and the longitudinal assoc

SUBMITTER: Choi B 

PROVIDER: S-EPMC9859724 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature