Safety of SABA Monotherapy in Asthma Management: a Systematic Review and Meta-analysis.

ABSTRACT:

Introduction

Short-acting β₂-agonist (SABA) reliever overuse is common in asthma, despite availability of inhaled corticosteroid (ICS)-based maintenance therapies, and may be associated with increased risk of adverse events (AEs). This systematic literature review (SLR) and meta-analysis aimed to investigate the safety and tolerability of SABA reliever monotherapy for adults and adolescents with asthma, through analysis of randomized controlled trials (RCTs) and real-world evidence.

Methods

An SLR of English-language publications between January 1996 and December 2021 included RCTs and observational studies of patients aged ≥ 12 years treated with inhaled SABA reliever monotherapy (fixed dose or as needed) for ≥ 4 weeks. Studies of terbutaline and fenoterol were e

SUBMITTER: Sriprasart T 

PROVIDER: S-EPMC9859883 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature