Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study.

ABSTRACT:

Purpose

There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors.

Methods

We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric hospitals between January 2010 and March 2022. Subjects with first available brain MRI and [Formula: see text] 3 months of clinical follow-up were included. Neuroimaging studies were reviewed, and clinical data collected. Annual symptomatic hemorrhage risk rates and cumulative risks were calculated using survival analysis and predictors of symptomatic hemorrhagic identi

SUBMITTER: Geraldo AF 

PROVIDER: S-EPMC9859903 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature