Ontology highlight
ABSTRACT:
SUBMITTER: Doran MH
PROVIDER: S-EPMC9859928 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Doran Matthew H MH Rynkiewicz Michael J MJ Rasicci David D Bodt Skylar M L SML Barry Meaghan E ME Bullitt Esther E Yengo Christopher M CM Moore Jeffrey R JR Lehman William W
The Journal of general physiology 20230112 3
Following binding to the thin filament, β-cardiac myosin couples ATP-hydrolysis to conformational rearrangements in the myosin motor that drive myofilament sliding and cardiac ventricular contraction. However, key features of the cardiac-specific actin-myosin interaction remain uncertain, including the structural effect of ADP release from myosin, which is rate-limiting during force generation. In fact, ADP release slows under experimental load or in the intact heart due to the afterload, thereb ...[more]