Analysis of bacterial diversity and community structure in gastric juice of patients with advanced gastric cancer.

ABSTRACT:

Background

The occurrence and development of gastric cancer are related to microorganisms, which can be used as potential biomarkers of gastric cancer.

Objective

To screen the microbiological markers of gastric cancer from the microorganisms of gastric juice.

Methods

Gastric juice samples were collected from 61 healthy people and 78 patients with gastric cancer (48 cases of early gastric cancer and 30 cases of advanced gastric cancer). The bacterial 16 S rRNA V1-V4 region of gastric juice samples was sequenced. The Shannon index, Simpson index, Ace index and Chao index were used to analyze the diversity of gastric juice samples. The RDP classifier Bayesian algorithm was used to analyze the community structure of 97% OTU representative sequences with similar levels. Li

SUBMITTER: Wei Q 

PROVIDER: S-EPMC9860007 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature