Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning.

ABSTRACT:

Background

Earlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced stages which are associated with poor survival. Developing non-invasive blood tests for early detection would be an important breakthrough.

Methods

The primary objective of the work presented here is to use a dataset that is prospectively collected, to quantify a set of cancer-associated proteins and construct multi-marker models with the capacity to predict PDAC years before diagnosis. The data used is part of a nested case-control study within the UK Collaborative Trial of Ovarian Cancer Screening and is comprised of 218 samples, collected from a total of 143 post-menopausal women who were diagnosed with pancreatic cancer within

SUBMITTER: Nene NR 

PROVIDER: S-EPMC9860022 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature