Dissolvable alginate hydrogel-based biofilm microreactors for antibiotic susceptibility assays.

ABSTRACT: Biofilms are found in many infections in the forms of surface-adhering aggregates on medical devices, small clumps in tissues, or even in synovial fluid. Although antibiotic resistance genes are studied and monitored in the clinic, the structural and phenotypic changes that take place in biofilms can also lead to significant changes in how bacteria respond to antibiotics. Therefore, it is important to better understand the relationship between biofilm phenotypes and resistance and develop approaches that are compatible with clinical testing. Current methods for studying antimicrobial susceptibility are mostly planktonic or planar biofilm reactors. In this work, we develop a new type of biofilm reactor-three-dimensional (3D) microreactors-to recreate biofilms in a microenvironment that bett

SUBMITTER: Pham LHP 

PROVIDER: S-EPMC9860113 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature