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Measurements of Na⁺-occluded intermediates during the catalytic cycle of the Na⁺/K⁺-ATPase provide novel insights into the mechanism of Na⁺ transport.

ABSTRACT: The Na⁺/K⁺-ATPase is an integral plasma membrane glycoprotein of all animal cells that couples the exchange of intracellular Na⁺ for extracellular K⁺ to the hydrolysis of ATP. The asymmetric distribution of Na⁺ and K⁺ is essential for cellular life and constitutes the physical basis of a series of fundamental biological phenomena. The pumping mechanism is explained by the Albers-Post model. It involves the presence of gates alternatively exposing Na⁺/K⁺-ATPase transport sites to the intracellular and extracellular sides and includes occluded states in which both gates are simultaneously closed. Unlike for K⁺, information is lacking about Na⁺-occluded intermediates, as occluded Na

SUBMITTER: Faraj SE

PROVIDER: S-EPMC9860123 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Dataset Information

Measurements of Na⁺-occluded intermediates during the catalytic cycle of the Na⁺/K⁺-ATPase provide novel insights into the mechanism of Na⁺ transport.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Measurements of Na+-occluded intermediates during the catalytic cycle of the Na+/K+-ATPase provide novel insights into the mechanism of Na+ transport.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Measurements of Na⁺-occluded intermediates during the catalytic cycle of the Na⁺/K⁺-ATPase provide novel insights into the mechanism of Na⁺ transport.