Molecular hallmarks of breast multiparametric magnetic resonance imaging during neoadjuvant chemotherapy.

ABSTRACT:

Purpose

To identify molecular basis of four parameters obtained from dynamic contrast-enhanced magnetic resonance imaging, including functional tumor volume (FTV), longest diameter (LD), sphericity, and contralateral background parenchymal enhancement (BPE).

Material and methods

Pretreatment-available gene expression profiling and different treatment timepoints MRI features were integrated for Spearman correlation analysis. MRI feature-related genes were submitted to hypergeometric distribution-based gene functional enrichment analysis to identify related Kyoto Encyclopedia of Genes and Genomes annotation. Gene set variation analysis was utilized to assess the infiltration of distinct immune cells, which were used to determine relationships between immune phenotypes and medi

SUBMITTER: Lin P 

PROVIDER: S-EPMC9860227 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature