Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection.

ABSTRACT: Platelets play a role not only in hemostasis and thrombosis, but also in inflammation and innate immunity. We previously reported that an activated form of tyrosyl-tRNA synthetase (YRS^ACT) has an extratranslational activity that enhances megakaryopoiesis and platelet production in mice. Here, we report that YRS^ACT mimics inflammatory stress inducing a unique megakaryocyte (MK) population with stem cell (Sca1) and myeloid (F4/80) markers through a mechanism dependent on Toll-like receptor (TLR) activation and type I interferon (IFN-I) signaling. This mimicry of inflammatory stress by YRS^ACT was studied in mice infected by lymphocytic choriomeningitis virus (LCMV). Using Sca1/EGFP transgenic mice, we demonstrated that IFN-I induced by YRS^ACT or LCM

SUBMITTER: Morodomi Y 

PROVIDER: S-EPMC9860251 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature