Ontology highlight
ABSTRACT:
SUBMITTER: Hossain ME
PROVIDER: S-EPMC9860338 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Hossain Md Emon ME Cevallos Ricardo Raul RR Zhang Ruowen R Hu Kejin K
iScience 20221228 1
Generation of induced pluripotent stem cells (iPSCs) is inefficient and stochastic. The underlying causes for these deficiencies are elusive. Here, we showed that the reprogramming factors (OCT4, SOX2, and KLF4, collectively OSK) elicit dramatic reprogramming stress even without the pro-oncogene MYC including massive transcriptional turbulence, massive and random deregulation of stress-response genes, cell cycle impairment, downregulation of mitotic genes, illegitimate reprogramming, and cytotox ...[more]