Death without progression as an endpoint to describe cardiac radiation effects in locally advanced non-small cell lung cancer.

ABSTRACT:

Background and purpose

Prior studies have examined associations of cardiovascular substructure dose with overall survival (OS) or cardiac events after chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC). Herein, we investigate an alternative endpoint, death without cancer progression (DWP), which is potentially more specific than OS and more sensitive than cardiac events for understanding CRT toxicity.

Materials and methods

We retrospectively reviewed records of 187 patients with locally advanced or oligometastatic NSCLC treated with definitive CRT from 2008 to 2016 at a single institution. Dosimetric parameters to the heart, lung, and ten cardiovascular substructures were extracted. Charlson Comorbidity Index (CCI), excluding NSCLC diagnosis, was used to stratify

SUBMITTER: Yegya-Raman N 

PROVIDER: S-EPMC9860414 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature