Bioequivalence studies of cetirizine tablets using the urine excretion data of healthy Ghanaian male volunteers.

ABSTRACT:

Background

In the wake of economic challenges, the role of generic medicines has become crucial in meeting the healthcare needs of people. Their use, however, can only be guaranteed if established to be bioequivalent to their corresponding innovator products.

Aim

In this study, we assess the suitability of a generic brand of cetirizine hydrochloride tablet to be used in place of the innovator brand on the Ghanaian market through bioequivalence assessment.

Method

An HPLC bioanalytical method was developed and validated for the detection and quantitation of cetirizine in a urine matrix. This was then used to quantify the amount of cetirizine excreted unchanged in urine samples of 12 healthy male volunteers collected over a 24-h period using a two-way crossover design ap

SUBMITTER: Onuh G 

PROVIDER: S-EPMC9860417 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature