AFP score and metroticket 2.0 perform similarly and could be used in a "within-ALL" clinical decision tool.

ABSTRACT:

Background & aims

Two recently developed composite models, the alpha-fetoprotein (AFP) score and Metroticket 2.0, could be used to select patients with hepatocellular carcinoma (HCC) who are candidates for liver transplantation (LT). The aim of this study was to compare the predictive performance of both models and to evaluate the net risk reclassification of post-LT recurrence between them using each model's original thresholds.

Methods

This multicenter cohort study included 2,444 adult patients who underwent LT for HCC in 47 centers from Europe and Latin America. A competing risk regression analysis estimating sub-distribution hazard ratios (SHRs) and 95% CIs for recurrence was used (Fine and Gray method). Harrell's adapted c-statistics were estimated. The net reclassifica

SUBMITTER: Pinero F 

PROVIDER: S-EPMC9860475 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature