Association of estimated white matter hyperintensity age with cognition in elderly with controlled hypertension.

ABSTRACT:

Introduction

Hypertension is associated with white matter hyperintensity (WMH) and cognitive impairment. Further, WMH is associated with cognitive impairment including executive, attention and visuospatial functions. The aim of this study was to investigate the effects of controlled hypertension (cHT) and previously developed concept, 'WMH age' on cognitive function and the mediating role of WMH in the effect of cHT on cognitive impairment.

Methods

We enrolled 855 Koreans without dementia aged 60 years or older, 326 of whom completed 2-year follow-up assessment. We measured their blood pressure thrice in a sitting position using an automated blood pressure monitoring device. We estimated 'WMH age' of every participant using previously developed WMH probability map of healthy

SUBMITTER: Sung Kim J 

PROVIDER: S-EPMC9860510 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature