Molecular Dynamics Simulation as a Tool to Identify Mutual Synergistic Folding Proteins.

ABSTRACT: Mutual synergistic folding (MSF) proteins belong to a recently emerged subclass of disordered proteins, which are disordered in their monomeric forms but become ordered in their oligomeric forms. They can be identified by experimental methods following their unfolding, which happens in a single-step cooperative process, without the presence of stable monomeric intermediates. Only a limited number of experimentally validated MSF proteins are accessible. The amino acid composition of MSF proteins shows high similarity to globular ordered proteins, rather than to disordered ones. However, they have some special structural features, which makes it possible to distinguish them from globular proteins. Even in the possession of their oligomeric three-dimensional structure, classification can only

SUBMITTER: Magyar C 

PROVIDER: S-EPMC9861041 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature