Chemical Profile and Biological Effects of an Herbal Mixture for the Development of an Oil-in-Water Cream.

ABSTRACT: Three individual hydroalcoholic extracts derived from Hamamelis virginiana leaves, Krameria lappacea root, Salix alba bark, and the resulting herbal mixture (HM) were assessed for the phytochemical profile as well as for antibacterial and cytotoxic potential. The chemical composition of the individual extracts and of their mixture was analyzed by chromatographical (LC-MS) and spectrophotometrical methods. The antimicrobial properties were evaluated by using the agar-well diffusion and the broth microdilution assays, whereas the potential cytotoxicity was investigated on human keratinocyte cell line by MTT method and apoptosis test. The HM composition revealed important amounts of valuable polyphenolic compounds provided from the individual extracts, having synergistic

SUBMITTER: Safta DA 

PROVIDER: S-EPMC9861053 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature