Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox.

ABSTRACT: Invasive fungal infections caused by Candida species remain a significant public health problem worldwide. The increasing prevalence of drug-resistant infections and a limited arsenal of antifungal drugs underscore the need for novel interventions. Here, we screened several classes of pharmacologically active compounds against mammalian diseases for antifungal activity. We found that the synthetic triazine-based compound melanogenin (Mel) 56 is fungicidal in Candida albicans laboratory and clinical strains with minimal inhibitory concentrations of 8-16 µg/mL. Furthermore, Mel56 has general antifungal activity in several non-albicans Candida species and the non-pathogenic yeast Saccharomyces cerevisiae. Surprisingly, Mel56 inhibited the yeast-to-hyphae t

SUBMITTER: Conrad KA 

PROVIDER: S-EPMC9861074 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature