Microbiome and Metabolome Variation as Indicator of Social Stress in Female Prairie Voles.

ABSTRACT: Social isolation is detrimental to the health of social mammals inducing neurochemical and hormonal changes related to depression and anxiety, as well as impairments of cardiovascular and immune functioning. Likewise, perceptions of loneliness are increasingly recognized as detrimental to human psychological well-being, cognitive functioning, and physical health. Few studies, however, have examined the impact of social isolation on the intestinal microbiome and metabolome. To better understand the impact of social isolation on these systems, intestinal microbiota, and the systemic impact via the gut-brain axis, we employed prairie voles. Physiological stress on female prairie voles (n = 22) either with a same-sex sibling (n = 11) or in isolation (n = 11) for four weeks demonstrated behavio

SUBMITTER: Nuccio DA 

PROVIDER: S-EPMC9861106 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature