Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.

ABSTRACT: The aim of this study was to disentangle the effects of various genetic factors on hippocampal subfield volumes using three different approaches: a biologically driven candidate gene approach, a hypothesis-free GWAS approach, and a polygenic approach, where AD risk alleles are combined with a polygenic risk score (PRS). The impact of these genetic factors was investigated in a large dementia-free general population cohort from the Study of Health in Pomerania (SHIP, n = 1806). Analyses were performed using linear regression models adjusted for biological and environmental risk factors. Hippocampus subfield volume alterations were found for APOE ε4, BDNF Val, and 5-HTTLPR L allele carriers. In addition, we were able to replicate GWAS findings, especially for rs17

SUBMITTER: Kirchner K 

PROVIDER: S-EPMC9861136 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature