Potential Therapies Targeting the Metabolic Reprogramming of Diabetes-Associated Breast Cancer.

ABSTRACT: In recent years, diabetes-associated breast cancer has become a significant clinical challenge. Diabetes is not only a risk factor for breast cancer but also worsens its prognosis. Patients with diabetes usually show hyperglycemia and hyperinsulinemia, which are accompanied by different glucose, protein, and lipid metabolism disorders. Metabolic abnormalities observed in diabetes can induce the occurrence and development of breast cancer. The changes in substrate availability and hormone environment not only create a favorable metabolic environment for tumorigenesis but also induce metabolic reprogramming events required for breast cancer cell transformation. Metabolic reprogramming is the basis for the development, swift proliferation, and survival of cancer cells. Metabolism must also be

SUBMITTER: Shum HCE 

PROVIDER: S-EPMC9861470 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature