SARS-CoV-2 mRNA Dual Immunization Induces Innate Transcriptional Signatures, Establishes T-Cell Memory and Coordinates the Recall Response.

ABSTRACT:

Background

mRNA vaccines have played a crucial role in controlling the SARS-CoV-2 global pandemic. However, the immunological mechanisms involved in the induction, magnitude and longevity of mRNA-vaccine-induced protective immunity are still unclear.

Methods

In our study, we used whole-RNA sequencing along with detailed immunophenotyping of antigen-specific T cells and humoral RBD-specific response to dual immunization with the Pfizer-BioNTech mRNA vaccine (BNT162b2) and correlated them with response to an additional dose, administered 10 months later, in order to comprehensively profile the immune response of healthy volunteers to BNT162b2.

Results

Primary dual immunization induced upregulation of the Type I interferon pathway and generated spike protein (S)-specific

SUBMITTER: Papadatou I 

PROVIDER: S-EPMC9861479 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature