Alternatively Spliced Isoforms of <i>MUC4</i> and <i>ADAM12</i> as Biomarkers for Colorectal Cancer Metastasis.

ABSTRACT: There is a pertinent need to develop prognostic biomarkers for practicing predictive, preventive and personalized medicine (PPPM) in colorectal cancer metastasis. The analysis of isoform expression data governed by alternative splicing provides a high-resolution picture of mRNAs in a defined condition. This information would not be available by studying gene expression changes alone. Hence, we utilized our prior data from an exon microarray and found ADAM12 and MUC4 to be strong biomarker candidates based on their alternative splicing scores and pattern. In this study, we characterized their isoform expression in a cell line model of metastatic colorectal cancer (SW480 & SW620). These two genes were found to be good prognostic indicators in two cohorts from The Cancer Genome

SUBMITTER: Althenayyan S 

PROVIDER: S-EPMC9861497 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature