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Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals.


ABSTRACT: Allergic asthma has traditionally been treated with inhaled and systemic glucocorticosteroids. A continuum of allergic fungal airways disease associated with Aspergillus fumigatus colonization and/or atopic immune responses that encompasses fungal asthma, severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis is now recognized along a phenotypic severity spectrum of T2-high immune deviation lung disease. Oral triazoles have shown clinical, anti-inflammatory and microbiologic efficacy in this setting; in the future inhaled antifungals may improve the therapeutic index. Humanized monoclonal antibody biologic agents targeting T2-high disease also show efficacy and promise of improved control in difficult cases. Developments in these areas are highlighted in this overview.

SUBMITTER: Moss RB 

PROVIDER: S-EPMC9861760 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals.

Moss Richard B RB  

Journal of fungi (Basel, Switzerland) 20230106 1


Allergic asthma has traditionally been treated with inhaled and systemic glucocorticosteroids. A continuum of allergic fungal airways disease associated with <i>Aspergillus fumigatus</i> colonization and/or atopic immune responses that encompasses fungal asthma, severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis is now recognized along a phenotypic severity spectrum of T2-high immune deviation lung disease. Oral triazoles have shown clinical, anti-inflammatory an  ...[more]

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