Trimethylamine N-Oxide Levels Are Associated with Severe Aortic Stenosis and Predict Long-Term Adverse Outcome.

ABSTRACT: Objective: Trimethylamine N-oxide (TMAO), a pathological microbial metabolite, is demonstrated to be related to cardiovascular diseases. This study was (1) to investigate the association between TMAO and aortic stenosis and (2) to determine the prognostic value of TMAO for predicting mortality after transcatheter aortic valve replacement (TAVR). Methods: 299 consecutive patients (77 (72−81) years, 58.2% male, Society of Thoracic Surgeons (STS) score 5.8 (4.9−9.3)) with severe aortic stenosis and 711 patients (59 (52−66) years, 51.9% male) without aortic stenosis were included in this retrospective study. A total of 126 pairs of patients were assembled by Propensity Score Matching. The primary outcome was all-cause mortality using survival analyses stratified by TMAO quartiles. Results: Pat

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9861904 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature