NucEnvDB: A Database of Nuclear Envelope Proteins and Their Interactions.

ABSTRACT: The nuclear envelope (NE) is a double-membrane system surrounding the nucleus of eukaryotic cells. A large number of proteins are localized in the NE, performing a wide variety of functions, from the bidirectional exchange of molecules between the cytoplasm and the nucleus to chromatin tethering, genome organization, regulation of signaling cascades, and many others. Despite its importance, several aspects of the NE, including its protein-protein interactions, remain understudied. In this work, we present NucEnvDB, a publicly available database of NE proteins and their interactions. Each database entry contains useful annotation including a description of its position in the NE, its interactions with other proteins, and cross-references to major biological repositories. In addition, the da

SUBMITTER: Baltoumas FA 

PROVIDER: S-EPMC9861991 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature