Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma.

ABSTRACT: The rate at which obesity is becoming an epidemic in many countries is alarming. Obese individuals have a high risk of developing elevated intraocular pressure and glaucoma. Additionally, glaucoma is a disease of epidemic proportions. It is characterized by neurodegeneration and neuroinflammation with optic neuropathy and the death of retinal ganglion cells (RGC). On the other hand, there is growing interest in microbiome dysbiosis, particularly in the gut, which has been widely acknowledged to play a prominent role in the etiology of metabolic illnesses such as obesity. Recently, studies have begun to highlight the fact that microbiome dysbiosis could play a critical role in the onset and progression of several neurodegenerative diseases, as well as in the development and progression of s

SUBMITTER: Pezzino S 

PROVIDER: S-EPMC9862076 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature