Dietary Patterns and Long-Term Outcomes in Patients with NAFLD: A Prospective Analysis of 128,695 UK Biobank Participants.

ABSTRACT: Large longitudinal studies exploring the role of dietary patterns in the assessment of long-term outcomes of NAFLD are still lacking. We conducted a prospective analysis of 128,695 UK Biobank participants. Cox proportional hazards models were used to estimate the risk associated with two dietary patterns for long-term outcomes of NAFLD. During a median follow-up of 12.5 years, 1925 cases of end-stage liver disease (ESLD) and 12,466 deaths occurred in patients with NAFLD. Compared with patients in the lowest quintile, those in the highest quintile of the diet quality score was negatively associated with the risks of ESLD and all-cause mortality (HR_Q5vsQ1: 0.76, 95% CI: 0.66-0.87, p < 0.001; HR_Q5vsQ1: 0.84, 95% CI: 0.79-0.88, p < 0.001, respectively)

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9862257 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature