Fructose Diet-Associated Molecular Alterations in Hypothalamus of Adolescent Rats: A Proteomic Approach.

ABSTRACT:

Background

The enhanced consumption of fructose as added sugar represents a major health concern. Due to the complexity and multiplicity of hypothalamic functions, we aim to point out early molecular alterations triggered by a sugar-rich diet throughout adolescence, and to verify their persistence until the young adulthood phase.

Methods

Thirty days old rats received a high-fructose or control diet for 3 weeks. At the end of the experimental period, treated animals were switched to the control diet for further 3 weeks, and then analyzed in comparison with those that were fed the control diet for the entire experimental period.

Results

Quantitative proteomics identified 19 differentially represented proteins, between control and fructose-fed groups, belonging to interm

SUBMITTER: D'Ambrosio C 

PROVIDER: S-EPMC9862284 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature