Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis.

ABSTRACT: (1) Background: Arteriovenous fistulas (AVFs) are the preferred access for hemodialysis. Unfortunately, about 60% of patients, especially female patients, fail to receive normal dialysis within one year after surgery because of AVF failure. However, the underlying mechanisms caused by sex differences in AVF failure remain unclear. (2) Methods: We performed analysis of DEGs and functional analysis with the dataset GSE119296 to reveal the biology underlying AVF failure. Immune responses were calculated using CIBERSORT. A protein-protein interaction network and hub gene were constructed using STRING and stepwise identification of potential drugs was performed online. (3) Results: Functional analysis showed that extracellular matrix reprogramming and PI3K-AKT pathway enrichment were significan

SUBMITTER: Hu K 

PROVIDER: S-EPMC9862581 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature