Expression of pH-Sensitive TRPC4 in Common Skin Tumors.

ABSTRACT: TRPCs (transient receptor potential classical or cation channels) play a crucial role in tumor biology, especially in the Ca²⁺ homeostasis in cancer cells. TRPC4 is a pH-sensitive member of this family of proteins. As solid tumors exhibit an inversed pH-gradient with lowered extracellular and increased intracellular pH, both contributing to tumor progression, TRPC4 might be a signaling molecule in the altered tumor microenvironment. This is the first study to investigate the expression profiles of TRPC4 in common skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM) and nevus cell nevi (NCN). We found that all SCCs, NCNs, and MMs show positive TRPC4-expression, while BCCs do only in about half of the analyzed samples. These data

SUBMITTER: Kurz B 

PROVIDER: S-EPMC9862651 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature