Dataset Information

A Clinical, Pathological, Epidemiological and Molecular Investigation of Recent Outbreaks of Peste des Petits Ruminants Virus in Domestic and Wild Small Ruminants in the Abu Dhabi Emirate, United Arab Emirates.

ABSTRACT: (1) Background: Peste des petits ruminants (PPR) is a highly contagious animal disease affecting small ruminants, leading to significant economic losses. There has been little published data on PPR virus (PPRV) infection in the United Arab Emirates (UAE); (2) Methods: four outbreaks reported in goats and Dama gazelle in 2021 were investigated using pathological and molecular testing; (3) Results: The infected animals showed symptoms of dyspnea, oculo-nasal secretions, cough, and diarrhea. Necropsy findings were almost similar in all examined animals and compliant to the classical forms of the disease. Phylogenetic analysis based on N gene and F gene partial sequences revealed a circulation of PPRV Asian lineage IV in the UAE, and these sequences clustered close to the sequences of PPRV from United Arab Emirates, Pakistan, Tajikistan and Iran; (4) Conclusions: PPRV Asian lineage IV is currently circulating in the UAE. To the best of our knowledge, this is a first study describing PPRV in domestic small ruminant in the UAE.

SUBMITTER: Ishag HZA

PROVIDER: S-EPMC9862675 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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A Clinical, Pathological, Epidemiological and Molecular Investigation of Recent Outbreaks of Peste des Petits Ruminants Virus in Domestic and Wild Small Ruminants in the Abu Dhabi Emirate, United Arab Emirates.

Ishag Hassan Zackaria Ali HZA Terab Abdelnasir Mohammed Adam AMA Eltahir Yassir Mohammed YM El Tigani-Asil El Tigani Ahmed ETA Khalil Nasereldien Altaib Hussein NAH Gasim Esamt Faisal Malik EFM Yuosf Mohd Farouk MF Al Yammahi Saeed Mohamed Saeed SMS Al Mansoori Asma Mohammed Amer AMA Al Muhairi Salama Suhail Mohammed SSM Al Hammadi Zulaikha Mohamed Abdel Hameed ZMAH Shah Asma Abdi Mohamed AAM Alherbawi Majd Mohamed Azmi Naser MMAN Al Nuaimat Mervat Mari Hassan MMH Bensalah Oum Keltoum OK Khalafalla Abdelmalik Ibrahim AI

Veterinary sciences 20230113 1

(1) Background: Peste des petits ruminants (PPR) is a highly contagious animal disease affecting small ruminants, leading to significant economic losses. There has been little published data on PPR virus (PPRV) infection in the United Arab Emirates (UAE); (2) Methods: four outbreaks reported in goats and Dama gazelle in 2021 were investigated using pathological and molecular testing; (3) Results: The infected animals showed symptoms of dyspnea, oculo-nasal secretions, cough, and diarrhea. Necrop ...[more]

PMID: 36669056

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Project description:BackgroundInfectious Bronchitis (IB), caused by the infectious bronchitis virus (IBV), is a significant contagious respiratory disease in the poultry industry. The emergence of new variants represents a global challenge for the diagnosis and control of the disease. Despite vaccination efforts in poultry farms in the Abu Dhabi Emirate, United Arab Emirates (UAE), outbreaks continue to occur, raising concerns about the efficacy of vaccination protocols and the potential emergence of new viral strains. This study aims to provide information on clinical, pathological, and genotypes of IBV detected within the Abu Dhabi Emirate, during 2022-2023.MethodsEpidemiological data were collected from twelve suspected IB outbreaks across seven broiler farms located in the Abu Dhabi Emirate. The cases were investigated through clinical and pathological examinations and Forty-six samples, including lung, spleen, kidney tissues, and oro-cloacal swabs, were collected for further analysis. The virus was detected by RT-qPCR assay, genotyping was determined by phylogenetic analysis of the Spike (S)-1 gene, and differentiation between field and vaccine strains was determined by comparing their sequences.ResultsThe age of the affected flocks varies from 2 to 5 weeks. The highest morbidity, mortality and case fatality rates were 36, 33, and 95%, respectively. Necropsy examination revealed characteristic respiratory and renal pathological lesions. Phylogenetic analysis revealed a co-circulation of three lineages of IBV genotype GI-13 or 4/91 serotype (81.8%), GI-1 or Massachusetts serotype (9.1%) and GI-23 or Middle East serotype (9.1%). Approximately 90.9% of the strains classified within GI-1 and G1-13 lineages are 99 to 100% identical to 4/91 and Mass serotypes, respectively, and are considered as vaccine strains. Two strains (9.1%) classified within GI-23 lineage have a < 99% identity to the 4/91 and Mass serotypes vaccine strains and are considered as filed strains.ConclusionCo-circulation of three IBV lineages (GI-13, GI-1, and GI-23) in the Abu Dhabi broiler flocks showing IB symptoms were detected. This complex scenario of different IBV lineages circulation may account for the persistent outbreaks despite vaccination efforts. The results of the study are crucial for optimum IB vaccination and monitoring strategies or designing new vaccines based on local IBV field strains.

Dataset Information

A Clinical, Pathological, Epidemiological and Molecular Investigation of Recent Outbreaks of Peste des Petits Ruminants Virus in Domestic and Wild Small Ruminants in the Abu Dhabi Emirate, United Arab Emirates.

Publications

A Clinical, Pathological, Epidemiological and Molecular Investigation of Recent Outbreaks of Peste des Petits Ruminants Virus in Domestic and Wild Small Ruminants in the Abu Dhabi Emirate, United Arab Emirates.

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